Different Types of Inflammation – Plus, A Rockstar Anti-Inflammatory Herb

When Good Inflammation Goes Bad

The trouble starts when this process doesn’t shut off. Chronic inflammation develops when immune cells keep releasing cytokines like TNF-α, IL-1β, and IL-6 long after the original threat is gone. Researchers increasingly separate this out as chronic systemic inflammation—a low-grade, body-wide state distinct from a normal local inflammatory flare, and one that can be measured through blood markers such as C-reactive protein, interleukins, and fibrinogen.¹ Unlike acute inflammation, chronic inflammation typically flies under the radar. As a result, it’s impossible to pin a number on how many American’s are affected. What researchers do know is that at least 50 percent of all deaths can be attributed to inflammation-related diseases such as coronary artery disease, stroke, cancer, diabetes, chronic kidney disease, non-alcoholic fatty liver disease, autoimmune diseases, and neurodegenerative conditions.^2,3

But here’s the thing—chronic inflammation doesn’t happen on its own. While autoimmune conditions, prolonged infection, or environmental toxins can be an underlying trigger, many lifestyle choices can also fuel ongoing low-grade inflammation. The most common culprits include:

• Poor diet.Regularly eating ultra-processed foods, added sugars, refined carbs, and unhealthy fats can prompt an immune response and alter gut bacteria.
• Excess body fat—especially deep visceral fat around your abdominal organs—releases inflammatory chemicals and cytokines into the bloodstream.
• Chronic stress.Ongoing stress keeps cortisol levels high, which can upend the body’s inflammatory and nervous pathways.
• Lack of sleep.Too little sleep and circadian rhythm disruptions increase pro-inflammatory cytokines and lower immune cell function.
• Sedentary lifestyle.Low levels of physical activity contribute to weight gain and systemic, low-grade inflammation.
• Smoking and tobacco,Using tobacco products releases inflammatory cells and damages the lining of blood vessels.
• Excess alcohol consumption.Heavy or regular drinking damages cells, alters the gut microbiome, and triggers toxic metabolic byproducts.⁴

Fortunately, you have the power to change these harmful habits—and that can have a profound impact on the level of inflammation in your body. The first step, however, is to identify any clues that inflammation may be quietly simmering throughout your body.

Signs You May Have Chronic Inflammation

Because chronic inflammation is systemic rather than localized to one sore joint or stubbed toe, you won’t feel it directly. Instead, it often shows up as vague, persistent symptoms rather than an obvious injury. These can include:

• Persistent fatigue that can’t be explained by poor sleep.⁵
• Recurrent low-grade fevers.⁶
• Joint or muscle pain without a clear injury.⁷
• Digestive issues.⁸
• Brain fog.⁹
• Skin issues such as rashes or unexplained itching.¹⁰
• Unintended weight changes.¹¹

None of these symptoms confirm chronic inflammation on their own. They often overlap with many other conditions. But a cluster of them, especially alongside elevated inflammatory blood markers, is worth a consultation with your health care provider.

Curcumin: The Ultimate Anti-Inflammatory

Adopting healthy anti-inflammatory habits can be a good step toward reducing chronic inflammation. But you can fight inflammation even more effectively by adding curcumin to the equation. Curcumin is the active compound in the curry spice turmeric and it’s loaded with powerful anti-inflammatory and antioxidant properties. This gives it the unique ability to fight both low-level inflammation and free radical damage—two factors linked to many chronic illnesses.

Studies show that curcumin curbs inflammation by downregulating the COX-2 enzyme in much the same way that aspirin or ibuprofen does. It also decreases iNOS enzymes, which are involved in the production of nitric oxide.¹² Nitric oxide is an important molecule that helps modulate vascular tone, insulin secretion, and more. But it can also play a key role in the disease-promoting effects of unchecked low-grade inflammation.¹³  In fact, clinical trials show that curcumin supplementation can help mitigate a wide variety of diseases linked to chronic inflammation.¹⁴

But for all its benefits, curcumin does have a downside. It turns out, this vibrant yellow compound isn’t readily absorbed by the body because it lacks solubility. This can limit its effectiveness. Adding insult to injury, curcumin is also rapidly metabolized in the gastrointestinal tract and is quickly eliminated by the body.¹⁵  To overcome these challenges, various forms of curcumin have been develop using different technologies to enhance absorption and bioavailability. These include adding piperine (black pepper extract), pairing it with turmeric essential oil, or formulating a water-soluble form of curcumin. While all of these technologies improve bioavailability to varying degrees, the most well-researched form employs a proprietary phytosome/phospholipid complex that binds curcumin to soy phosphatidylcholine, a fat-soluble carrier that helps it cross the gut lining. Listed on Supplement Facts labels under the name Meriva, clinical trials show that the phytosome form of curcumin increases absorption by as much as 29-fold.¹⁶

What the Clinical Trials Show

Higher blood levels only matter if they translate into real outcomes, and Meriva has repeatedly shown the following real world benefits:

Osteoarthritis. In an early study of 50 osteoarthritis patients taking just 200 mg of Meriva, pain/function scores fell 58 percent and treadmill walking distance more than quadrupled after just three months, alongside a sharp drop in C-reactive protein—far outperforming the comparison group.¹⁷ A follow-up eight-month study in 100 patients confirmed long-term improvement in joint pain, function, and inflammatory markers.¹⁸

Kidney disease. In patients with chronic kidney disease, Meriva supplementation was associated with reduced inflammation, lower lipid peroxidation, and favorable shifts in gut microbiota composition, suggesting benefits that extend well beyond the joints.¹⁹

Non-alcoholic fatty liver disease (NAFLD). A clinical trial in the journal Drug Research found that Meriva improved liver health in those with NAFLD by reducing body mass index (BMI), waist circumference, serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), total cholesterol, LDL cholesterol, triglycerides, and non-high-density lipoprotein cholesterol. The researchers concluded that supplementing with curcumin on a short-term basis improves liver fat levels and transaminase (enzymes released by liver cells) in patients with NAFLD.²⁰

Cardiovascular disease. A randomized clinical trial evaluating bioavailable curcumin concentrates like Meriva reported lower oxidative stress markers, improvements in arterial flexibility, and better blood pressure regulation during exercise.²¹

The Takeaway

Inflammation itself isn’t the enemy—it’s a protective tool your body uses for healing. Problems occur when inflammation becomes chronic and systemic, quietly contributing to conditions ranging from heart disease to arthritis. Curcumin shows real anti-inflammatory promise, but only if the body can absorb and use it. The most well-researched form is a phytosome/ phospholipid curcumin with proven benefits. As always, however, talk with your doctor before starting any supplement, especially if you take blood thinners or other medications.

1. Zotova N, Zhuravleva Y, Chereshnev V, et al. Acute and chronic systemic inflammation: features and differences in the pathogenesis, and integral criteria for verification and differentiation. International Journal of Molecular Science. 2023;24(2):1144.
2. Furman D, Campisi J, Verdin E, et al. Chronic inflammation in the etiology of disease across the life span. Nature Medicine. 2019;25(12):1822-32.
3. Chavda VP, Feehan J, Apostolopoulos V. Inflammation: the cause of all diseases. Cells. 2024;13(22):1906.
4. Ruiz-Núñez B, Pruimboom L, Dijck-Brouwer DA, et al. Lifestyle and nutritional imbalances associated with Western diseases: causes and consequences of chronic systemic low-grade inflammation in an evolutionary context. Journal of Nutritional Biochemistry. 2013;24(7):1183-201.
5. Lacourt TE, Vichaya EG, Chiu GS, et al. The high costs of low-grade inflammation: persistent fatigue as a consequence of reduced cellular-energy availability and non-adaptive energy expenditure. Frontiers in Behavioral Neuroscience. 2018;12:78.
6. Galloway J, Cope AP. The ying and yang of fever in rheumatic disease. Clinical Medicine (London). 2015;15(3):288-91.
7. Josefsson D, Danielsson L, Jakobsson M. Systemic inflammation mediating the relationship between lifestyle factors and musculoskeletal pain: a systematic review. Frontiers in Pain Research. 2026;7:1755744.
8. Ribaldone DG, Pellicano R, Actis GC. Inflammation in gastrointestinal disorders: prevalent socioeconomic factors. Clinical and Experimental Gastroenterology. 2019;12:321-9.
9. Balter LJ, Bosch JA, Aldred S, et al. Selective effects of acute low-grade inflammation on human visual attention. 2019;202:116098.
10. Liu Y, Wang H, Taylor M, et al. Classification of human chronic inflammatory skin disease based on single-cell immune profiling. Science Immunology. 2022;7(70):eabl9165.
11. Vasunilashorn S. Retrospective reports of weight change and inflammation in the US National Health and Nutrition Examination Survey. Journal of Obesity. 2013;2013:601534.
12. Peng Y, Ao M, Dong B, et al. Anti-inflammatory effects of curcumin in the inflammatory diseases: status, limitations and countermeasures. Drug Design, Development and Therapy. 2021;15:4503-25.
13. Korhonen R, Lahti A, Kankaanranta H, et al. Nitric oxide production and signaling in inflammation. Current Drug Targets, Inflammation and Allergy. 2005;4(4):471-9.
14. Zafar A, Lahori D, Namit AF, et al. Curcumin in inflammatory complications: therapeutic applications and clinical evidence. International Journal of Molecular Science, 2025;26:9366.
15. Jäger R, Lowery RP, Calvanese AV, et al. Comparative absorption of curcumin formulations. Nutrition Journal. 2014;13:11.
16. Cuomo J, Appendino G, Dern AS, et al. Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. Journal of Natural Products. 2011;74(4):664-9.
17. Belcaro G, Cesarone MR, Dugall M, et al. Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Medica. 2010 ;52(2 Suppl 1):55-62.
18. Belcaro G, Cesarone M R, Dugall M, et al. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients.Alternative Medicine Review. 2010;15(4), 337-44.
19. Pivari F, Mingione A, Piazzini G, et al. Curcumin supplementation (Meriva^®) modulates inflammation, lipid peroxidation and gut microbiota composition in chronic kidney disease. Nutrients. 2022;14(1):231.
20. Panahi Y, Kianpour P, Mohtashami R, et al. Efficacy and safety of phytosomal curcumin in non-alcoholic fatty liver disease: a randomized controlled trial. Drug Research (Stuttg). 2017;67(4):244-251.
21. Hajleh MNA, Al-Dujaili EAS. Effects of turmeric concentrate on cardiovascular risk factors and exercise-induced oxidative stress in healthy volunteers; an exploratory study. Advanced Pharmaceutical Bulletin. 2023;13(3):601-10.

This article is for informational purposes only. This article is not, nor is it intended to be, a substitute for professional medical advice, diagnosis, or treatment and should never be relied upon for specific medical advice.