Pro+ Synbiotic | Kyo-Dophilus | Probiotic

Pro+ Synbiotic

Intestinal Balance and Support*

| Now Available! |

Available Sizes
50 count, 25 single serve packs
Kyo-Dophilus® Pro+ Synbiotic

Intestinal Balance and Support*

Kyo-Dophilus® Pro+ Synbiotic comes in tasty chewable tablets that contain a specially selected prebiotic and a community of nine probiotic strains including The Friendly Trio®. Synbiotic is a term used for probiotics and prebiotics which are combined to provide a synergistic beneficial effect in the microbiome. The BioEcolians® prebiotic in Pro+ contributes to the population of Lactobacilli and Bifidobacteria species by feeding the good bacteria to help maintain bacterial balance.*

If you experience occasional intestinal distress, keep your microbiome strong and well populated with this prebiotic + probiotic to support improvement in regularity and relief from bloating and gas discomfort.* A balanced digestive system also promotes a healthy immune response and inhibits the growth of bad bacteria.*

†† The probiotic strains in this product have been identity-verified using DNA sequencing

Wakunaga of America’s Kyo-Dophilus Pro+ Synbiotic has been fully tested by Nutrasource under the IGEN™ Program**.
This product does not contain common GMO/GE genes or proteins.
Wakunaga utilizes Nutrasource for 3rd party quality control testing of its products.
**IGEN™ Certification Mark is a registered trademark of Nutrasource .

20 Billion
Gluten Free
Soy Free
Dairy Free
No Artificial Color
No Artificial Flavor
No Refrigeration

Kyo-Dophilus Probiotics are formulated to support healthy digestive and immune systems.* Our probiotics deliver efficacy, quality and extended live cell viability, without refrigeration.

The Friendly Trio®

The Friendly Trio® is the core of our formulations. The Friendly Trio® is a clinically studied proprietary blend of human strain Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum

  • L. gasseri has been shown to support your body’s GI function and immune health.*
  • B. bifidum may regulate healthy gut flora and enhance immunity by reducing inflammation.*
  • B. longum is known to normalize bowel movements.*


Take two chewable tablets of Kyo-Dophilus Pro+ Synbiotic once daily to balance your GI system and promote digestive health for your general wellbeing.*

The product packaging you receive may contain additional details or may differ from what is shown on our website.  Please refer to the information included with your product, do not rely solely on the the details shown on this page.

*These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Pro+ Synbiotic Reviews

Taste Good and Work Well


I love the taste of this product, and it works quite well for healthy digestion. Highly recommended for traveling with the convenient packs.

Noticed A Much Calmer Stomach and Better Digestion


I really felt the benefits of this product. It took my body a few days to adjust (which meant it was working) and I noticed a much calmer stomach and…

Great For Someone Who Hates Swallowing Pills

B. Abode

The solely largest thing that hinders me from keeping consistent with my daily probiotics is taking a pill. Guys, I hate taking pills. I thought at some point in my…

Helping My 13 Year Old’s IBS


My daughter takes this product for her IBS and it’s incredible helps and saves a lot of heartache for me from an upset 13 year old. Life is already improving…

Helps With My Food Intolerances!


It isn’t often that I can find supplements that work with my food intolerance. I love that the Kyo-Dolphilus is in easy to carry single packets, gluten free, and are…

Kyo-Dophilus® FAQs

View All


What does the “CFU” number mean?

Most supplements are measured in milligrams. Probiotics, on the other hand, are measured in CFUs (Colony Forming Units). This refers to the amount of viable, live bacteria that are capable of dividing and forming colonies. CFU counts are generally stated in billions.


Do Kyo-Dophilus Probiotics need to be refrigerated?

Because of the unique and proprietary processing methods used in the manufacture of Kyo-Dophilus® Probiotics, the bacteria are stable at room temperature and therefore do not require refrigeration. Kyo-Dophilus selected bacteria strains are dormant and do not become active until they are introduced to moisture, as when consumed with a meal or liquid. Kyo-Dophilus guarantees that “at the time of expiry (or consumption),” you are getting the bacteria count (CFU) that is stated on the label.


Where are your Kyo-Dophilus products manufactured?

Our finished products are manufactured in California, USA at our state-of-the-art GMP certified facility.


What is the source of your Kyo-Dophilus probiotics?

The three main strains used in all of our Kyo-Dophilus products (The Friendly Trio®): L. gasseri KS-13, B. bifidum G9-1 and B. longum MM-2 are derived from a human source from a one-time, proprietary and non-invasive method. The other strains in Kyo-Dophilus Multi 9 and Kyo-Dophilus Max products are either sourced from human, dairy, or fermented grains. (Due to processing method, they do not contain any dairy or grain allergens)